刘志洪 教授

一、基本信息：

刘志洪，教授，博士生导师，1949伟德国际源自英国党委常委、副董事长。国家杰出青年科学基金获得者，曾入选科技部“创新人才推进计划”和“万人计划”科技领军人才。已在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Mater.、Nat. Commun.等期刊发表SCI论文150余篇，他引近万次，申请、授权专利20余项，参编学术专著5部。

二、联系方式：

邮箱：zhhliu@hubu.edu.cn

课题组网站：分子诊断与精准治疗研究中心

三、研究方向：

1.活体高分辨成像：发展近红外二区光学新方法，实现深组织分子可视化，推动疾病早期诊断。

2.脑部传感与监测：构建植入式微电极光电化学传感技术，高时空分辨解析脑内化学信号与病理机制。

3.脑靶向递送系统：开发生物膜仿生伪装递送策略，高效穿透血脑屏障，提升脑部药物富集效率。

四、科研项目与成果：

（一）近五年承担的科研项目

1.国家自然科学基金重大科研仪器研制项目，2024.01.01～2028.12.31，890万元，在研；

2.国家自然科学基金区域创新发展联合基金重点项目，2026.01.01～2029.12.31，258万元，在研；

3.湖北省技术创新计划重大科技项目，2025.08.01～2027.08.31，100万元，在研；

4.武汉市科技局特区计划项目，2024.06.01～2026.06.01，200万元，在研；

5.国家自然科学基金委科技活动专项项目，2024.1.1～2024.12.31；12.5万元，结题。

（二）代表性论文：

1. Jiangnan Ouyang, Yanqiu Li, Rui Chen, Xianlong Su,* Zhihong Liu, * Low-power-activated afterglow nanoprobes with naked-eye visibility for high-contrast imaging of brain inflammation, Angew. Chem. Int. Ed. 2026, 65, 14, e3145716.

2. Miantai Ye, Xiaoyu Wang, Jingwen Zou, Wei Sun, Weijie Chi,* Zhiqiang Mao,* Zhihong Liu,* Breaking shackles of molecular weight and emission for NIR-II fluorophores by regulating Columb attraction interaction,Nat. Commun.2025, 16, 8007.

3. Jing Wang, Jinhua Shang, Shanshan Yu, Mengru Lin, Xue Gong, Xiaoqing Liu, Prof.Zhihong Liu*, Fuan Wang*, Self-adaptive activation of DNAzyme nanoassembly for synergistically combined gene therapy,Angew. Chem. Int. Ed.2024, 63, e202417363.

4. Siyu Chi, Li Zhang, Hemei Cheng, Yaran Chang, Yaoyao Zhao*, Xiayan Wang,Zhihong Liu*, Biomimetic Nanocomposites Camouflaged with Hybrid Cell Membranes for Accurate Therapy of Early-Stage Glioma,Angew. Chem. Int. Ed.2023, 62, e202304419.

5. Dan Song, Chenchen Li, Mengting Zhu, Siyu Chi, Prof.Zhihong Liu*, Tracking hepatic ischemia-reperfusion injury in real time with a reversible NIR-IIb fluorescent redox probe,Angew. Chem. Int. Ed.2022, 61,e202212721

6. Pengzhan Wang, Le Yu, Jiankang Gong, Jianhua Xiong, Soyu Zi, Hua Xie, Fan Zhang, Zhiqiang Mao*,Zhihong Liu*, Jong Seung Kim*, An activity-based fluorescent probe for imaging fluctuations of peroxynitrite (ONOO-) in the Alzheimer's disease brain,Angew. Chem. Int. Ed.2022, 61,e202206894

7. Meng Zhang, Zijun Wang, Yunlong Shao, Yaoyao Zhao*,Zhihong Liu*, Complement-opsonized NIR-IIb emissive immunotracer for dynamically monitoring neutrophils in inflammation-related diseases,Adv. Mater.2022, 34, 2203477.

8. Tingting Wu,YingLiu, Yu Cao*,Zhihong Liu*, Engineering macrophage exosome disguised biodegradable nanoplatform for enhanced sonodynamic therapy of glioblastoma,Adv. Mater.2022, 34, 2110364.

9. Xiaoxue Ye, Xing Wang, Yao Kong, Mengjiao Dai, Dongxue Han*,Zhihong Liu*,FRET modulated signaling: a versatile strategy to construct photoelectrochemical microsensors for in vivo analysis,Angew. Chem. Int. Ed.2021, 60, 11774-11778.

10. Tao Liang, Zhen Li*, Peipei Wang, Fangzhou Zhao, Jizhou Liu,Zhihong Liu*,Breaking Through the Signal-to-Background Limit of Upconversion Nanoprobes Using a Target-Modulated Sensitizing Switch.J. Am. Chem. Soc.2018, 140, 14696-14703.